#Pathway_id Name KOs total_family total_family_found Count Count_pct Abund Abund_pct Abund_DLM2 Abund_pct_DLM2 Abund_GEM2 Abund_pct_GEM2 Abund_LCM1 Abund_pct_LCM1 Abund_PLM2 Abund_pct_PLM2 00780 "Biotin metabolism" K00652+K01423 11 2 3 0.03 176.34 0.01 0.03 0.00 0.34 0.00 175.87 0.02 0.10 0.00 00785 "Lipoic acid metabolism" K03644+K03800+K03801 4 3 7 0.07 452.63 0.03 11.82 0.01 33.32 0.02 400.35 0.04 7.14 0.00 00641 "3-Chloroacrylic acid degradation" K00001+K00128+K01563 4 3 40 0.38 2927.05 0.19 12.68 0.01 45.90 0.02 2853.58 0.31 14.90 0.00 04080 "Neuroactive ligand-receptor interaction" K05770 297 1 1 0.01 25.47 0.00 0.12 0.00 0.14 0.00 25.10 0.00 0.12 0.00 00650 "Butanoate metabolism" K00004+K00019+K00022+K00023+K00074+K00100+K00114+K00128+K00135+K00139+K00161+K00162+K00163+K00170+K00171+K00172+K00239+K00240+K00241+K00242+K00244+K00245+K00246+K00248+K00626+K00634+K00929+K01028+K01029+K01034+K01035+K01039+K01640+K01652+K01653+K01692+K01715+K01782+K01896+K03366+K03821+K07511+K07514+K07515+K07516 67 45 291 2.80 27537.07 1.76 1854.27 1.45 3403.21 1.58 17634.53 1.92 4645.07 1.53 00351 "1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation" K00206+K00465 8 2 6 0.06 450.85 0.03 2.63 0.00 1.08 0.00 444.80 0.05 2.34 0.00 01040 "Biosynthesis of unsaturated fatty acids" K00059+K00232+K00507+K07513+K07515+K10255+K10257+K10804+K10805 27 9 83 0.80 6161.41 0.39 360.80 0.28 691.21 0.32 4179.11 0.46 930.29 0.31 05014 "Amyotrophic lateral sclerosis (ALS)" K00491+K03781+K04426+K04565+K08738 43 5 12 0.12 1000.61 0.06 14.02 0.01 7.33 0.00 972.03 0.11 7.22 0.00 03010 "Ribosome" K02863+K02864+K02867+K02871+K02874+K02876+K02878+K02879+K02881+K02884+K02886+K02887+K02888+K02890+K02892+K02895+K02897+K02899+K02902+K02904+K02906+K02907+K02909+K02911+K02916+K02926+K02931+K02933+K02935+K02939+K02945+K02948+K02952+K02954+K02956+K02959+K02961+K02963+K02965+K02967+K02968+K02970+K02982+K02986+K02988+K02990+K02994+K02996 147 48 109 1.05 52753.03 3.37 8595.27 6.70 15280.24 7.10 5707.22 0.62 23170.31 7.63 00281 "Geraniol degradation" K00022+K00155+K00632+K01041+K01692+K01913+K07508+K07509+K07511+K07513+K07514+K07515+K07516 14 13 92 0.88 8796.07 0.56 707.67 0.55 1387.40 0.64 4834.46 0.53 1866.54 0.61 00550 "Peptidoglycan biosynthesis" K00824+K01000+K01446+K01447+K01448+K01449+K01915+K01921+K01924+K01925+K01928+K01929+K02563+K03587+K05362+K05364+K05365+K06153+K11066 21 19 126 1.21 11468.57 0.73 1046.61 0.82 1779.94 0.83 6044.44 0.66 2597.58 0.86 00280 "Valine, leucine and isoleucine degradation" K00020+K00022+K00128+K00140+K00157+K00166+K00167+K00186+K00248+K00249+K00253+K00263+K00382+K00626+K00632+K00822+K00826+K01028+K01029+K01640+K01692+K01847+K01848+K01849+K01964+K01965+K01966+K01968+K01969+K05605+K05606+K07508+K07509+K07511+K07513+K07514+K07515+K07516+K08683+K09478+K09699+K11381+K11410 51 43 250 2.40 20162.54 1.29 1278.58 1.00 2012.97 0.94 14076.53 1.53 2794.48 0.92 00710 "Carbon fixation in photosynthetic organisms" K00025+K00026+K00029+K00615+K00812+K00813+K00873+K00927+K01006+K01595+K01623+K01624+K01783+K01803+K01807+K02446+K03841+K11532 34 18 160 1.54 20666.13 1.32 2033.72 1.59 3650.83 1.70 9628.93 1.05 5352.65 1.76 00471 "D-Glutamine and D-glutamate metabolism" K00261+K01425+K01776+K01924+K01925 6 5 62 0.60 4642.51 0.30 50.58 0.04 182.46 0.08 4341.22 0.47 68.26 0.02 00680 "Methane metabolism" K00114+K00121+K00122+K00123+K00124+K00125+K00127+K00192+K00197+K00297+K00430+K00436+K00492+K00532+K00533+K00600+K01070+K03396+K03518+K03519+K03520+K03781+K03782+K05299+K08348+K08349+K08350+K08685 49 28 105 1.01 12738.67 0.81 1095.01 0.85 1907.03 0.89 6936.41 0.76 2800.23 0.92 04115 "p53 signaling pathway" K06641+K08738+K10133 57 3 7 0.07 695.99 0.04 2.60 0.00 1.66 0.00 688.73 0.08 3.00 0.00 04011 "MAPK signaling pathway - yeast" K01759+K11228+K11231 39 3 197 1.89 24693.50 1.58 2321.17 1.81 4283.63 1.99 11845.75 1.29 6242.95 2.06 00252 "Alanine and aspartate metabolism" K00161+K00162+K00163+K00278+K00382+K00609+K00610+K00627+K00812+K00813+K00822+K01270+K01424+K01579+K01744+K01755+K01756+K01775+K01779+K01872+K01876+K01893+K01939+K01940+K01953+K01959+K01960+K02433+K02434+K02435 45 30 226 2.17 21598.33 1.38 1474.42 1.15 3235.46 1.50 13770.02 1.50 3118.43 1.03 00251 "Glutamate metabolism" K00135+K00139+K00260+K00261+K00262+K00264+K00265+K00266+K00294+K00383+K00764+K00812+K00813+K00820+K00926+K01425+K01583+K01585+K01776+K01885+K01886+K01915+K01919+K01920+K01948+K01950+K01951+K01955+K01956+K02433+K02434+K02435 47 32 219 2.11 17604.50 1.12 748.18 0.58 1714.31 0.80 13915.49 1.52 1226.53 0.40 00072 "Synthesis and degradation of ketone bodies" K00019+K00626+K01028+K01029+K01640 7 5 28 0.27 3311.86 0.21 336.37 0.26 634.43 0.29 1437.43 0.16 903.63 0.30 00640 "Propanoate metabolism" K00016+K00114+K00128+K00140+K00170+K00171+K00172+K00249+K00625+K00626+K00822+K00925+K01034+K01035+K01659+K01692+K01720+K01847+K01848+K01849+K01895+K01899+K01900+K01902+K01903+K01905+K01913+K01961+K01962+K01963+K01964+K01965+K01966+K02160+K03416+K03417+K05605+K05606+K07511+K07514+K07515 59 41 234 2.25 20384.03 1.30 1261.29 0.98 2167.88 1.01 14119.67 1.54 2835.20 0.93 04150 "mTOR signaling pathway" K03259+K04373+K04688 30 3 20 0.19 1114.92 0.07 3.27 0.00 1.68 0.00 1108.67 0.12 1.29 0.00 01030 "Glycan structures - biosynthesis 1" K00710+K00728+K00733+K03844+K07432+K07441+K09667 105 7 52 0.50 7131.75 0.46 722.99 0.56 1187.35 0.55 3426.27 0.37 1795.13 0.59 00051 "Fructose and mannose metabolism" K00066+K00100+K00847+K00848+K00850+K00882+K00895+K00966+K00971+K01103+K01623+K01624+K01711+K01803+K01809+K01840+K02377+K02446+K03332+K03841+K11532 50 21 84 0.81 7338.71 0.47 364.78 0.28 636.37 0.30 5442.63 0.59 894.92 0.29 02010 "ABC transporters - General" K01995+K01996+K01997+K01998+K01999+K02000+K02001+K02002+K02003+K02004+K02006+K02010+K02011+K02012+K02013+K02015+K02016+K02017+K02018+K02020+K02031+K02032+K02033+K02034+K02035+K02036+K02037+K02038+K02040+K02041+K02042+K02045+K02046+K02047+K02048+K02049+K02050+K02051+K02062+K02063+K02064+K02065+K02066+K02067+K02068+K02071+K02072+K02073+K02193+K02194+K02195+K02424+K05685+K05776+K05777+K05813+K05815+K05816+K05845+K05846+K05847+K06073+K06857+K06858+K09686+K09687+K09689+K09690+K09691+K09693+K09695+K09697+K09808+K09810+K09811+K09812+K09813+K09814+K09815+K09816+K09817+K09819+K09969+K09970+K09971+K09972+K10000+K10004+K10009+K10010+K10017+K10019+K10021+K10025+K10038+K10041+K10107+K10109+K10111+K10112+K10117+K10119+K10190+K10191+K10195+K10199+K10230+K10232+K10233+K10235+K10239+K10243+K10439+K10440+K10441+K10539+K10542+K10543+K10544+K10545+K10551+K10558+K10562+K11070+K11071+K11072+K11073+K11074+K11075+K11076+K11080+K11084+K11085 293 133 425 4.09 42576.32 2.72 2509.17 1.96 4402.23 2.05 29465.66 3.21 6199.26 2.04 00562 "Inositol phosphate metabolism" K00010+K01092+K01858 31 3 7 0.07 426.54 0.03 2.52 0.00 0.86 0.00 419.85 0.05 3.31 0.00 00521 "Streptomycin biosynthesis" K00067+K00845+K00973+K01092+K01710+K01790+K01835+K01858 14 8 39 0.38 2787.07 0.18 37.83 0.03 31.27 0.01 2701.26 0.29 16.71 0.01 04111 "Cell cycle - yeast" K02178+K02831+K03114 103 3 15 0.14 830.95 0.05 3.27 0.00 1.35 0.00 825.18 0.09 1.14 0.00 01031 "Glycan structures - biosynthesis 2" K02527+K02840+K02844+K03276+K03279+K03857+K08098 78 7 31 0.30 1874.80 0.12 14.97 0.01 53.54 0.02 1793.79 0.20 12.50 0.00 00310 "Lysine degradation" K00022+K00128+K00143+K00149+K00164+K00252+K00471+K00626+K00658+K00824+K00825+K01423+K01692+K01843+K01844+K07511+K07514+K07515+K07516 46 19 243 2.34 21384.76 1.37 1485.03 1.16 2751.51 1.28 13469.37 1.47 3678.86 1.21 00660 "C5-Branched dibasic acid metabolism" K01652+K01653+K01902+K01903+K10218 9 5 57 0.55 4031.09 0.26 50.63 0.04 188.33 0.09 3722.34 0.41 69.78 0.02 00040 "Pentose and glucuronate interconversions" K00012+K00065+K00848+K00853+K00854+K00874+K00880+K00963+K01625+K01728+K01730+K01783 41 12 78 0.75 4480.20 0.29 47.36 0.04 49.28 0.02 4351.68 0.47 31.88 0.01 00340 "Histidine metabolism" K00013+K00128+K00492+K00599+K00603+K00765+K00817+K01089+K01270+K01458+K01468+K01479+K01496+K01523+K01593+K01693+K01712+K01745+K01814+K01892+K02501+K04486+K05602 34 23 180 1.73 23937.16 1.53 2301.99 1.80 4254.14 1.98 11093.58 1.21 6287.44 2.07 03410 "Base excision repair" K01151+K01246+K01247+K01971+K01972+K02335+K03575+K03648+K03649+K03652+K03660+K05522+K07462+K10563+K10747+K10771+K10772+K10773+K10800+K10801 34 20 57 0.55 7010.34 0.45 703.96 0.55 1199.95 0.56 3329.85 0.36 1776.58 0.59 03430 "Mismatch repair" K01141+K01971+K01972+K03111+K03555+K03572+K03601+K03602+K03657+K07456+K07462+K10747 32 12 36 0.35 2285.72 0.15 47.88 0.04 30.80 0.01 2194.12 0.24 12.91 0.00 01051 "Biosynthesis of ansamycins" K00615 2 1 20 0.19 2871.19 0.18 343.58 0.27 610.26 0.28 1002.27 0.11 915.07 0.30 00940 "Phenylpropanoid biosynthesis" K00430+K00517+K01188+K01904+K05349 19 5 64 0.62 9765.66 0.62 969.73 0.76 1942.60 0.90 4132.03 0.45 2721.29 0.90 00030 "Pentose phosphate pathway" K00033+K00034+K00036+K00615+K00616+K00850+K00851+K00852+K00874+K00948+K01057+K01619+K01623+K01624+K01625+K01690+K01783+K01807+K01810+K01835+K01839+K02446+K03841+K11532 42 24 76 0.73 11267.50 0.72 1260.19 0.98 2380.08 1.11 4046.35 0.44 3580.87 1.18 00530 "Aminosugars metabolism" K00075+K00326+K00698+K00790+K00820+K00972+K01183+K01207+K01443+K01836+K02472+K02474+K02564+K03431+K04042+K07106+K11528 38 17 123 1.18 10876.64 0.69 680.33 0.53 1229.24 0.57 7181.19 0.78 1785.88 0.59 00510 "N-Glycan biosynthesis" K00721+K00729+K00810+K00902+K03844+K07432+K07441 35 7 37 0.36 4009.78 0.26 385.92 0.30 606.27 0.28 2085.44 0.23 932.15 0.31 00760 "Nicotinate and nicotinamide metabolism" K00157+K00278+K00322+K00324+K00325+K00763+K00767+K00858+K00952+K00969+K01081+K01239+K01513+K01916+K01950+K03517+K03783+K03784+K06989+K08722+K08723 30 21 75 0.72 6167.61 0.39 437.30 0.34 633.51 0.29 4166.68 0.45 930.12 0.31 00450 "Selenoamino acid metabolism" K00392+K00394+K00395+K00599+K00681+K00789+K00860+K00956+K00958+K01008+K01042+K01251+K01697+K01738+K01739+K01758+K01760+K01761+K01874 22 19 183 1.76 20829.82 1.33 1789.04 1.40 3055.17 1.42 11422.78 1.24 4562.83 1.50 00062 "Fatty acid elongation in mitochondria" K00022+K07508+K07509+K07511+K07512+K07515 8 6 68 0.65 6841.18 0.44 684.00 0.53 1268.23 0.59 3076.24 0.34 1812.71 0.60 00330 "Arginine and proline metabolism" K00261+K00273+K00286+K00294+K00318+K00491+K00611+K00812+K00813+K00819+K00824+K00926+K01259+K01470+K01473+K01474+K01478+K01571+K01625+K01750+K01755+K01881+K01887+K01940+K01948+K11142 53 26 134 1.29 11847.37 0.76 688.84 0.54 1868.12 0.87 8065.59 0.88 1224.83 0.40 00670 "One carbon pool by folate" K00288+K00297+K00548+K00560+K00600+K00601+K00602+K00603+K00604+K00605+K01491+K01746+K01934+K01938+K03465+K08289+K11175 21 17 67 0.64 4151.39 0.27 126.16 0.10 96.58 0.04 3877.45 0.42 51.20 0.02 00500 "Starch and sucrose metabolism" K00012+K00688+K00689+K00690+K00691+K00694+K00695+K00697+K00700+K00702+K00703+K00705+K00845+K00847+K00963+K00975+K01087+K01176+K01178+K01179+K01182+K01187+K01188+K01193+K01194+K01198+K01212+K01225+K01226+K01513+K01810+K01835+K01838+K05342+K05343+K05344+K05349+K08678+K08679 67 39 150 1.44 13376.85 0.85 1065.44 0.83 1908.07 0.89 7741.59 0.84 2661.75 0.88 00770 "Pantothenate and CoA biosynthesis" K00053+K00077+K00207+K00606+K00826+K00859+K00867+K00954+K00997+K01464+K01513+K01652+K01653+K01687+K01918+K03525 24 16 106 1.02 7749.71 0.50 139.75 0.11 249.12 0.12 7262.10 0.79 98.74 0.03 00196 "Photosynthesis - antenna proteins" K02284+K02285+K02286+K02287+K02288+K02289+K02290 40 7 14 0.13 9572.51 0.61 1457.32 1.14 2933.65 1.36 699.30 0.08 4482.22 1.48 00622 "Toluene and xylene degradation" K00055+K00492+K01576+K01666+K01781+K01856+K03380+K03381+K10217 15 9 42 0.40 4706.29 0.30 343.83 0.27 614.05 0.29 2845.61 0.31 902.81 0.30 00410 "beta-Alanine metabolism" K00128+K00137+K00207+K00249+K00797+K00822+K01270+K01464+K01579+K01692+K01918+K05605+K07511+K07514+K07515 24 15 107 1.03 8367.97 0.53 375.79 0.29 738.00 0.34 6311.71 0.69 942.48 0.31 00623 "2,4-Dichlorobenzoate degradation" K00448+K00449+K00465+K00481+K03384+K07519 14 6 14 0.13 984.24 0.06 2.46 0.00 26.05 0.01 947.49 0.10 8.24 0.00 00631 "1,2-Dichloroethane degradation" K00114+K00128+K01561+K01563 5 4 22 0.21 1938.25 0.12 11.94 0.01 30.38 0.01 1883.75 0.21 12.18 0.00 00625 "Tetrachloroethene degradation" K00100+K02586+K02588+K02591 7 4 7 0.07 445.18 0.03 0.03 0.00 0.30 0.00 444.72 0.05 0.13 0.00 02020 "Two-component system - General" K00066+K00244+K00245+K00246+K00370+K00371+K00626+K00689+K00766+K01034+K01035+K01609+K01657+K01695+K01696+K01915+K02040+K02106+K02259+K02488+K02491+K02556+K02657+K02658+K02659+K02660+K02667+K02668+K03407+K04771+K07636+K07637+K07638+K07639+K07640+K07641+K07642+K07643+K07644+K07645+K07646+K07647+K07648+K07649+K07650+K07651+K07652+K07653+K07654+K07655+K07656+K07657+K07658+K07659+K07660+K07666+K07668+K07669+K07670+K07673+K07674+K07675+K07676+K07677+K07678+K07679+K07680+K07681+K07682+K07683+K07684+K07689+K07690+K07692+K07694+K07695+K07696+K07697+K07698+K07699+K07701+K07704+K07705+K07708+K07709+K07710+K07711+K07712+K07714+K07716+K07717+K07718+K07768+K07769+K07771+K07773+K07775+K07776+K07777+K07778+K07787+K07788+K07789+K07799+K08082+K08083+K08348+K08349+K08350+K08475+K08479+K10125+K10126+K10255+K10681+K11328+K11331+K11354+K11356+K11357+K11383 239 121 401 3.86 43892.23 2.80 3769.66 2.94 6906.71 3.21 23322.41 2.54 9893.46 3.26 00900 "Terpenoid biosynthesis" K00795+K00806+K01823 8 3 7 0.07 422.75 0.03 24.84 0.02 51.23 0.02 287.07 0.03 59.60 0.02 00361 "gamma-Hexachlorocyclohexane degradation" K00120+K00492+K00493+K00517+K01061+K01561+K01563+K01860+K03380+K03381+K03384 22 11 63 0.61 5915.60 0.38 321.58 0.25 640.76 0.30 4076.28 0.44 876.98 0.29 00240 "Pyrimidine metabolism" K00207+K00226+K00254+K00384+K00525+K00527+K00560+K00609+K00610+K00756+K00758+K00761+K00762+K00857+K00876+K00940+K00943+K00945+K00962+K01081+K01119+K01464+K01465+K01485+K01489+K01493+K01494+K01518+K01520+K01591+K01937+K01955+K01956+K02335+K02428+K02825+K03465+K03783+K03784+K04765+K08693+K08722+K08723+K08728+K09903+K10807 73 46 342 3.29 36970.35 2.36 3495.18 2.73 6307.48 2.93 18955.57 2.06 8212.12 2.71 00150 "Androgen and estrogen metabolism" K00492+K00599+K01130 19 3 61 0.59 9292.76 0.59 952.13 0.74 1793.27 0.83 3857.61 0.42 2689.75 0.89 00380 "Tryptophan metabolism" K00022+K00128+K00155+K00157+K00164+K00252+K00453+K00486+K00493+K00599+K00626+K00669+K00816+K01426+K01432+K01501+K01556+K01593+K01692+K01867+K01932+K03392+K03393+K03781+K03782+K04103+K07511+K07514+K07515+K07516+K10217 50 31 213 2.05 23304.26 1.49 1987.09 1.55 3734.13 1.74 12159.57 1.32 5423.48 1.79 00632 "Benzoate degradation via CoA ligation" K00074+K00120+K00239+K00240+K00241+K00242+K00244+K00245+K00246+K00252+K00626+K01034+K01035+K01426+K01501+K01512+K01692+K01913+K04109+K04110+K05549+K07511+K07514+K07515+K07535+K07538+K07550+K10215 67 28 156 1.50 13469.84 0.86 722.98 0.56 1486.06 0.69 9364.43 1.02 1896.38 0.62 00480 "Glutathione metabolism" K00031+K00033+K00036+K00383+K00432+K00681+K00797+K00799+K01255+K01256+K01270+K01469+K01581+K01919+K01920+K04097+K10807+K11142+K11185+K11186+K11206 38 21 102 0.98 12393.42 0.79 1368.19 1.07 2457.88 1.14 4916.03 0.54 3651.32 1.20 04640 "Hematopoietic cell lineage" K05091 78 1 12 0.12 609.50 0.04 3.27 0.00 1.44 0.00 603.71 0.07 1.08 0.00 00630 "Glyoxylate and dicarboxylate metabolism" K00015+K00018+K00025+K00026+K00042+K00050+K00104+K00122+K00123+K00124+K00125+K00127+K00288+K00436+K00532+K00533+K01091+K01432+K01458+K01491+K01637+K01638+K01647+K01681+K01682+K01816+K01938+K08348+K08349+K08350+K08692+K11473 57 32 114 1.10 9578.17 0.61 491.00 0.38 724.81 0.34 7367.60 0.80 994.76 0.33 01057 "Biosynthesis of type II polyketide products" K05556 1 1 7 0.07 236.82 0.02 0.05 0.00 3.70 0.00 227.74 0.02 5.32 0.00 00561 "Glycerolipid metabolism" K00005+K00128+K00655+K00864+K01046+K03429+K06117+K06119 41 8 43 0.41 3042.63 0.19 38.40 0.03 34.75 0.02 2953.48 0.32 16.00 0.01 00362 "Benzoate degradation via hydroxylation" K00448+K00449+K00465+K00481+K00632+K01055+K01576+K01607+K01666+K01781+K01856+K01857+K03381+K04098+K05549+K07508+K07509+K07513+K07823+K10217+K10218 49 21 75 0.72 6280.95 0.40 406.63 0.32 1034.01 0.48 3834.26 0.42 1006.06 0.33 00260 "Glycine, serine and threonine metabolism" K00003+K00018+K00050+K00058+K00060+K00100+K00108+K00130+K00133+K00273+K00282+K00283+K00302+K00303+K00304+K00305+K00314+K00315+K00382+K00499+K00600+K00605+K00639+K00643+K00830+K00831+K00872+K00928+K00998+K01079+K01620+K01697+K01733+K01752+K01754+K01758+K01868+K01875+K01878+K01880+K02203+K06720 64 42 209 2.01 16883.27 1.08 717.87 0.56 1131.68 0.53 13898.76 1.51 1134.97 0.37 00565 "Ether lipid metabolism" K00655+K01062 12 2 4 0.04 267.27 0.02 10.49 0.01 0.10 0.00 256.33 0.03 0.35 0.00 00364 "Fluorobenzoate degradation" K01061+K01856+K01860+K03381+K03384+K05549 10 6 12 0.12 2758.42 0.18 325.86 0.25 594.64 0.28 943.92 0.10 893.99 0.29 00920 "Sulfur metabolism" K00380+K00381+K00387+K00390+K00392+K00394+K00395+K00640+K00641+K00651+K00860+K00956+K00958+K01082+K01738+K01739+K01760+K05301+K10150 27 19 151 1.45 12523.78 0.80 509.84 0.40 725.17 0.34 10324.80 1.12 963.98 0.32 04530 "Tight junction" K04424+K06103 63 2 12 0.12 606.96 0.04 3.26 0.00 1.43 0.00 601.17 0.07 1.09 0.00 00360 "Phenylalanine metabolism" K00055+K00146+K00270+K00285+K00430+K00457+K00492+K00529+K00812+K00813+K00817+K00824+K00832+K01426+K01451+K01593+K01666+K01912+K05708+K05710+K05711+K10797 38 22 125 1.20 12301.29 0.79 769.29 0.60 1420.13 0.66 8207.48 0.89 1904.40 0.63 00071 "Fatty acid metabolism" K00001+K00022+K00128+K00232+K00248+K00249+K00252+K00255+K00493+K00496+K00529+K00626+K00632+K01692+K01782+K01825+K01897+K01909+K06445+K07508+K07509+K07511+K07513+K07514+K07515+K07516+K09478 34 27 206 1.98 19358.76 1.24 1387.34 1.08 2696.27 1.25 11612.59 1.26 3662.56 1.21 00130 "Ubiquinone biosynthesis" K00329+K00330+K00331+K00332+K00333+K00334+K00335+K00336+K00337+K00338+K00340+K00341+K00343+K00568+K01661+K01911+K02548+K02549+K02551+K02552+K03179+K03182+K03183+K03184+K03185+K03688+K08680 38 27 110 1.06 17177.90 1.10 1604.37 1.25 2978.89 1.38 8156.53 0.89 4438.11 1.46 00621 "Biphenyl degradation" K00055+K01666+K10616 15 3 10 0.10 524.62 0.03 8.51 0.01 8.55 0.00 504.69 0.05 2.87 0.00 00750 "Vitamin B6 metabolism" K00097+K00157+K00831+K00868+K01733+K03472+K03474+K06215+K08681 14 9 35 0.34 1837.25 0.12 38.32 0.03 20.76 0.01 1759.54 0.19 18.63 0.01 00910 "Nitrogen metabolism" K00260+K00261+K00262+K00264+K00265+K00266+K00284+K00285+K00360+K00362+K00363+K00366+K00367+K00368+K00369+K00370+K00371+K00372+K00376+K00459+K00605+K00926+K01424+K01425+K01501+K01673+K01725+K01744+K01745+K01758+K01760+K01915+K01916+K01948+K01953+K02193+K02194+K02195+K02197+K02198+K02199+K02200+K02305+K02567+K02586+K02587+K02588+K02591+K02592+K02594+K02595+K03385+K04013+K04014+K04488+K05601+K08345+K08346+K10534+K10535 107 60 214 2.06 19115.19 1.22 930.93 0.73 1684.03 0.78 14570.69 1.59 1929.54 0.64 03090 "Type II secretion system" K01493+K02237+K02238+K02240+K02242+K02243+K02244+K02245+K02278+K02280+K02453+K02454+K02455+K02456+K02458+K02459+K02460+K02654+K02657+K02658+K02659+K02660+K02666+K02667+K02668+K02669 78 26 226 2.17 26634.99 1.70 2353.38 1.84 4420.52 2.05 13548.05 1.48 6313.05 2.08 00401 "Novobiocin biosynthesis" K00210+K00220+K00812+K00813+K00817+K00832+K04517 10 7 28 0.27 1820.12 0.12 47.88 0.04 93.17 0.04 1650.63 0.18 28.44 0.01 04310 "Wnt signaling pathway" K04427+K04496 100 2 5 0.05 2150.91 0.14 293.54 0.23 587.69 0.27 370.73 0.04 898.95 0.30 04020 "Calcium signaling pathway" K00491+K04854+K05850+K05864+K08041+K08042+K08043+K08044+K08047+K08048+K08049 129 11 25 0.24 3723.31 0.24 323.56 0.25 598.90 0.28 1892.24 0.21 908.59 0.30 00540 "Lipopolysaccharide biosynthesis" K00677+K00748+K00912+K00979+K01627+K02517+K02527+K02535+K02536+K02840+K02844+K03270+K03276+K03279 31 14 57 0.55 4238.93 0.27 41.21 0.03 86.31 0.04 4085.96 0.45 25.45 0.01 03030 "DNA replication" K01972+K02314+K02316+K02335+K02337+K02338+K02339+K02340+K02341+K02342+K02343+K03111+K03469+K03470+K03471+K03763+K10747 50 17 129 1.24 16609.18 1.06 1730.88 1.35 3062.75 1.42 7382.68 0.80 4432.88 1.46 03450 "Non-homologous end-joining" K01971+K10979 19 2 4 0.04 132.42 0.01 3.55 0.00 0.17 0.00 127.85 0.01 0.85 0.00 00643 "Styrene degradation" K00146+K00465+K01039+K01426+K01501+K01502+K01555+K01666+K01800 19 9 21 0.20 1296.05 0.08 5.89 0.00 13.65 0.01 1270.33 0.14 6.17 0.00 00220 "Urea cycle and metabolism of amino groups" K00128+K00137+K00145+K00147+K00611+K00618+K00619+K00620+K00657+K00797+K00818+K00930+K00931+K01270+K01426+K01428+K01429+K01430+K01438+K01457+K01480+K01581+K01583+K01585+K01611+K01755+K01940+K01941+K01948+K09472+K10536 48 31 133 1.28 11703.53 0.75 543.96 0.42 2018.66 0.94 8630.12 0.94 510.80 0.17 00523 "Polyketide sugar unit biosynthesis" K00067+K00973+K01710+K01790 4 4 12 0.12 1286.24 0.08 0.18 0.00 3.49 0.00 1279.68 0.14 2.89 0.00 00230 "Purine metabolism" K00087+K00088+K00106+K00364+K00365+K00525+K00527+K00601+K00602+K00758+K00759+K00760+K00764+K00769+K00860+K00873+K00926+K00939+K00940+K00942+K00948+K00951+K00956+K00958+K00962+K00988+K01081+K01119+K01120+K01129+K01139+K01239+K01241+K01428+K01429+K01430+K01483+K01486+K01487+K01488+K01492+K01509+K01513+K01514+K01515+K01516+K01518+K01524+K01588+K01589+K01756+K01768+K01769+K01839+K01923+K01933+K01939+K01945+K01951+K01952+K02335+K02428+K03783+K03784+K04765+K07816+K08041+K08042+K08043+K08044+K08045+K08046+K08047+K08048+K08049+K08289+K08312+K08693+K08722+K08723+K10807+K11175+K11177+K11178+K11265 129 85 613 5.90 71770.37 4.59 6791.48 5.30 12148.46 5.65 35645.61 3.88 17184.83 5.66 00020 "Citrate cycle (TCA cycle)" K00025+K00026+K00030+K00031+K00161+K00162+K00163+K00164+K00170+K00171+K00172+K00176+K00234+K00235+K00239+K00240+K00241+K00242+K00244+K00245+K00246+K00382+K00627+K00658+K01647+K01648+K01679+K01681+K01682+K01899+K01900+K01902+K01903+K01959+K01960 50 35 203 1.95 17435.84 1.11 1047.64 0.82 1719.67 0.80 12683.81 1.38 1984.72 0.65 04612 "Antigen processing and presentation" K04079 41 1 1 0.01 59.41 0.00 0.00 0.00 0.12 0.00 59.27 0.01 0.02 0.00 00190 "Oxidative phosphorylation" K00234+K00235+K00239+K00240+K00241+K00242+K00244+K00245+K00246+K00329+K00330+K00331+K00332+K00333+K00334+K00335+K00336+K00337+K00338+K00340+K00341+K00343+K00356+K00405+K00406+K00411+K00412+K00413+K00425+K00426+K00937+K01507+K02108+K02109+K02110+K02111+K02112+K02113+K02114+K02115+K02117+K02118+K02119+K02120+K02122+K02123+K02124+K02126+K02128+K02155+K02257+K02258+K02259+K02274+K02275+K02276+K02301+K02826+K02828+K03661+K03885+K03934+K03935+K03940+K03941+K03942+K03943+K03953+K03955+K05572+K05576+K05578+K05579+K05580+K05581+K05582+K05584+K05585+K05586+K05587+K05588 200 81 195 1.88 22016.70 1.41 1790.42 1.40 3053.65 1.42 12654.63 1.38 4518.01 1.49 03060 "Protein export" K03070+K03071+K03072+K03073+K03074+K03075+K03076+K03100+K03101+K03106+K03110+K03116+K03118+K03210+K03424 24 15 41 0.39 4027.50 0.26 404.76 0.32 684.03 0.32 1971.50 0.21 967.22 0.32 00100 "Biosynthesis of steroids" K00099+K00355+K00795+K00805+K00869+K00919+K01597+K01662+K01823+K03526+K03527+K05356+K10960 47 13 28 0.27 3692.96 0.24 369.85 0.29 669.13 0.31 1672.59 0.18 981.39 0.32 03440 "Homologous recombination" K01159+K02335+K03111+K03550+K03551+K03553+K03581+K03582+K03583+K03584+K03629+K03655+K04066+K06187+K07462 46 15 46 0.44 3657.27 0.23 369.45 0.29 579.31 0.27 1838.21 0.20 870.30 0.29 00720 "Reductive carboxylate cycle (CO2 fixation)" K00025+K00026+K00031+K00170+K00171+K00172+K00176+K00239+K00240+K00241+K00242+K00244+K00245+K00246+K00259+K01007+K01595+K01648+K01679+K01681+K01682+K01895+K01902+K01903 32 24 166 1.60 13997.07 0.89 593.66 0.46 1219.81 0.57 11087.91 1.21 1095.69 0.36 00983 "Drug metabolism - other enzymes" K00088+K00106+K00207+K00569+K00758+K00760+K00762+K00857+K00876+K01044+K01464+K01489+K01951 22 13 172 1.65 16441.49 1.05 1126.64 0.88 2058.63 0.96 10451.69 1.14 2804.53 0.92 04210 "Apoptosis" K02861+K08738 63 2 4 0.04 465.11 0.03 2.48 0.00 1.12 0.00 460.39 0.05 1.11 0.00 00592 "alpha-Linolenic acid metabolism" K00232+K00632+K10527 14 3 66 0.63 5252.50 0.34 340.04 0.27 682.61 0.32 3305.52 0.36 924.33 0.30 00300 "Lysine biosynthesis" K00003+K00133+K00143+K00215+K00674+K00821+K00825+K00841+K00928+K01439+K01586+K01655+K01705+K01714+K01778+K01928+K01929+K04567+K04568+K05822+K05823+K05825+K05830+K10206 39 24 199 1.91 16772.98 1.07 943.97 0.74 1864.21 0.87 11985.42 1.31 1979.38 0.65 00960 "Alkaloid biosynthesis II" K01044+K01913+K08081 11 3 13 0.13 896.14 0.06 16.56 0.01 115.78 0.05 714.22 0.08 49.58 0.02 00903 "Limonene and pinene degradation" K00120+K00128+K00155+K00206+K00492+K00517+K01692+K01913+K07511+K07514+K07515 21 11 123 1.18 11455.50 0.73 678.94 0.53 1408.79 0.65 7526.22 0.82 1841.55 0.61 00620 "Pyruvate metabolism" K00016+K00025+K00026+K00027+K00029+K00101+K00102+K00128+K00138+K00161+K00162+K00163+K00170+K00171+K00172+K00382+K00625+K00626+K00627+K00873+K00925+K01006+K01007+K01069+K01512+K01571+K01595+K01638+K01649+K01655+K01663+K01734+K01759+K01895+K01905+K01959+K01960+K01961+K01962+K01963+K02160+K03777+K03778 67 43 376 3.62 36449.03 2.33 2721.31 2.12 4552.48 2.12 22738.86 2.48 6436.38 2.12 00272 "Cysteine metabolism" K00016+K00640+K00812+K00813+K01011+K01738+K01739+K01740+K01752+K01758+K01760+K01883+K10150 21 13 78 0.75 4620.95 0.30 97.51 0.08 66.01 0.03 4427.97 0.48 29.46 0.01 02040 "Flagellar assembly" K02387+K02388+K02389+K02390+K02391+K02392+K02393+K02394+K02395+K02396+K02400+K02401+K02409+K02412+K02417+K02419+K02420+K02424+K02556+K02557 54 20 34 0.33 2052.85 0.13 2.71 0.00 27.24 0.01 2015.58 0.22 7.33 0.00 00930 "Caprolactam degradation" K00022+K00055+K01692+K01913+K06446+K07511+K07514+K07515+K07516 14 9 93 0.89 8385.84 0.54 710.37 0.55 1389.67 0.65 4421.39 0.48 1864.41 0.61 00195 "Photosynthesis" K02108+K02109+K02110+K02111+K02112+K02113+K02114+K02115+K02635+K02636+K02637+K02641+K02694+K02699+K02704+K02706+K02724+K08902+K08903 63 19 39 0.38 9358.38 0.60 1262.64 0.98 2333.50 1.08 2211.21 0.24 3551.02 1.17 00061 "Fatty acid biosynthesis" K00059+K00208+K00645+K00647+K00648+K00666+K01716+K01961+K01962+K01963+K02160+K02372+K09458+K10780+K11263 30 15 60 0.58 5474.60 0.35 405.98 0.32 725.27 0.34 3421.03 0.37 922.32 0.30 04010 "MAPK signaling pathway" K04367+K04372+K04373+K04420+K04421+K04424+K04425+K04426+K04427+K04442+K04443+K04444+K04445+K04460+K04854 175 15 29 0.28 3370.28 0.22 303.94 0.24 590.33 0.27 1573.37 0.17 902.63 0.30 01032 "Glycan structures - degradation" K01132+K01207+K01227+K10532 21 4 19 0.18 821.25 0.05 6.37 0.00 2.43 0.00 806.39 0.09 6.07 0.00 02060 "Phosphotransferase system (PTS)" K02744+K02745+K02749+K02750+K02752+K02753+K02755+K02756+K02757+K02760+K02763+K02764+K02765+K02768+K02769+K02770+K02773+K02774+K02777+K02778+K02779+K02787+K02788+K02790+K02791+K02793+K02794+K02795+K02796+K02798+K02799+K02800+K02802+K02803+K02804+K02806+K02808+K02809+K02810+K02812+K02813+K02817+K02818+K02819+K02821+K08483+K08484+K10984+K11183+K11191+K11192+K11194+K11198+K11199+K11200 98 55 38 0.37 2131.20 0.14 84.24 0.07 6.48 0.00 2032.73 0.22 7.75 0.00 00860 "Porphyrin and chlorophyll metabolism" K00228+K00231+K00595+K00643+K00798+K01599+K01698+K01719+K01749+K01772+K01845+K01885+K02226+K02232+K02257+K02259+K02301+K02302+K02303+K02492+K02493+K02494+K02495+K03394+K03403+K03404+K03428+K04040+K06042+K09882+K09883 85 31 65 0.63 5640.90 0.36 363.54 0.28 619.03 0.29 3763.32 0.41 895.01 0.29 00400 "Phenylalanine, tyrosine and tryptophan biosynthesis" K00014+K00210+K00220+K00270+K00500+K00766+K00800+K00812+K00813+K00817+K00832+K00891+K01609+K01626+K01657+K01658+K01695+K01696+K01713+K01735+K01736+K01817+K01850+K01866+K01889+K01890+K03785+K03786+K03856+K04092+K04093+K04516+K04517+K04518+K05358+K05359+K06001+K06208 48 38 128 1.23 12058.71 0.77 851.71 0.66 1720.42 0.80 7609.98 0.83 1876.61 0.62 00472 "D-Arginine and D-ornithine metabolism" K00273+K00824 2 2 3 0.03 83.14 0.01 2.39 0.00 0.52 0.00 78.79 0.01 1.45 0.00 00430 "Taurine and hypotaurine metabolism" K00259+K00625+K00681+K00925+K03852 15 5 29 0.28 3300.72 0.21 359.74 0.28 605.88 0.28 1436.31 0.16 898.79 0.30 00120 "Bile acid biosynthesis" K00001+K00100+K00128+K00492+K00632+K01442+K07508+K07509+K07513 22 9 67 0.64 4414.07 0.28 31.33 0.02 90.59 0.04 4260.37 0.46 31.78 0.01 04140 "Regulation of autophagy" K08333 21 1 17 0.16 966.68 0.06 3.27 0.00 1.55 0.00 960.65 0.10 1.21 0.00 00908 "Zeatin biosynthesis" K00791 4 1 1 0.01 78.70 0.01 7.86 0.01 0.06 0.00 70.54 0.01 0.25 0.00 04360 "Axon guidance" K05102+K05103+K05105+K05111+K05112+K05113+K05743+K05744 80 8 12 0.12 609.50 0.04 3.27 0.00 1.44 0.00 603.71 0.07 1.08 0.00 03420 "Nucleotide excision repair" K01971+K01972+K02335+K03657+K03701+K03702+K03703+K03723+K10747 48 9 31 0.30 3941.44 0.25 342.23 0.27 578.08 0.27 2159.13 0.24 862.00 0.28 00520 "Nucleotide sugars metabolism" K00012+K00067+K00963+K00973+K01198+K01209+K01710+K01784+K01790+K08678+K08679+K10012 20 12 52 0.50 4023.29 0.26 37.33 0.03 159.09 0.07 3759.78 0.41 67.09 0.02 03020 "RNA polymerase" K02999+K03002+K03006+K03010+K03018+K03021+K03022+K03040+K03041+K03042+K03043+K03044+K03045+K03046+K03047+K03049+K03055+K03060+K03086+K03087+K03088+K03089+K03092 59 23 53 0.51 6836.94 0.44 707.81 0.55 1260.84 0.59 3060.99 0.33 1807.31 0.60 04110 "Cell cycle" K02178+K06067+K06632+K06633+K06641 91 5 16 0.15 855.94 0.05 3.32 0.00 4.53 0.00 846.26 0.09 1.84 0.00 00253 "Tetracycline biosynthesis" K01961+K01962+K01963+K02160 4 4 21 0.20 1562.90 0.10 49.97 0.04 22.26 0.01 1481.63 0.16 9.03 0.00 05012 "Parkinson's disease" K00234+K00235+K00411+K00412+K00413+K02126+K02128+K03934+K03935+K03940+K03941+K03942+K03943+K03953+K03955+K05688+K05864+K08738+K08844 109 19 106 1.02 10477.14 0.67 360.44 0.28 649.60 0.30 8569.79 0.93 897.33 0.30 00740 "Riboflavin metabolism" K00793+K00794+K00953+K01513 15 4 11 0.11 806.59 0.05 28.71 0.02 18.80 0.01 752.76 0.08 6.32 0.00 04510 "Focal adhesion" K05096+K05097+K05098+K06269+K06272 125 5 20 0.19 1126.14 0.07 3.27 0.00 1.57 0.00 1120.01 0.12 1.28 0.00 05111 "Vibrio cholerae pathogenic cycle" K03087+K03092+K10909+K10916+K10942 42 5 163 1.57 22889.02 1.46 2292.27 1.79 4257.28 1.98 10100.05 1.10 6239.42 2.06 00730 "Thiamine metabolism" K00788+K00878+K00941+K00949+K01516+K03148+K03149+K03151+K03707+K04487 19 10 32 0.31 4093.89 0.26 369.32 0.29 602.77 0.28 2216.60 0.24 905.20 0.30 01053 "Biosynthesis of siderophore group nonribosomal peptides" K02364+K02552+K04781+K04784 29 4 39 0.38 3282.87 0.21 24.08 0.02 173.17 0.08 3023.56 0.33 62.06 0.02 00564 "Glycerophospholipid metabolism" K00006+K00057+K00105+K00111+K00655+K00981+K00995+K00998+K01048+K01096+K01126+K05939+K06131+K08744 59 14 77 0.74 7216.02 0.46 447.38 0.35 751.60 0.35 5072.89 0.55 944.16 0.31 00010 "Glycolysis / Gluconeogenesis" K00001+K00016+K00114+K00128+K00131+K00134+K00161+K00162+K00163+K00170+K00171+K00172+K00382+K00627+K00845+K00850+K00873+K00886+K00927+K01512+K01568+K01623+K01624+K01689+K01785+K01803+K01810+K01834+K01835+K01837+K01895+K02446+K03841+K04022+K05344+K11532 56 36 347 3.34 37109.09 2.37 2866.05 2.24 5059.62 2.35 21964.59 2.39 7218.83 2.38 00052 "Galactose metabolism" K00035+K00845+K00849+K00850+K00963+K01187+K01193+K01631+K01684+K01784+K01835+K02079 38 12 70 0.67 6278.76 0.40 411.77 0.32 738.52 0.34 4165.99 0.45 962.48 0.32 01055 "Biosynthesis of vancomycin group antibiotics" K01710 1 1 3 0.03 321.56 0.02 0.05 0.00 0.87 0.00 319.92 0.03 0.72 0.00 00906 "Carotenoid biosynthesis - General" K02291+K02294+K09846+K10208+K10209+K10210 27 6 9 0.09 393.18 0.03 15.02 0.01 0.24 0.00 375.97 0.04 1.94 0.00 00271 "Methionine metabolism" K00548+K00558+K00604+K00641+K00651+K00789+K00797+K00832+K00899+K01243+K01251+K01611+K01697+K01739+K01740+K01758+K01760+K01874+K08968+K10764 38 20 104 1.00 6277.55 0.40 182.16 0.14 110.81 0.05 5876.72 0.64 107.86 0.04 00970 "Aminoacyl-tRNA biosynthesis" K00604+K01866+K01867+K01868+K01869+K01870+K01872+K01873+K01874+K01875+K01876+K01878+K01880+K01881+K01883+K01885+K01886+K01887+K01889+K01890+K01892+K01893+K04567+K04568 28 24 73 0.70 6643.05 0.42 475.62 0.37 997.85 0.46 4160.66 0.45 1008.91 0.33 00790 "Folate biosynthesis" K00072+K00201+K00202+K00203+K00204+K00205+K00320+K00357+K00441+K00443+K00796+K00950+K01495+K01529+K01633+K01664+K01665+K01737+K02619+K03388+K03390+K08264+K11260+K11261 52 24 321 3.09 38393.40 2.45 3490.70 2.72 6212.78 2.89 19641.36 2.14 9048.57 2.98 00460 "Cyanoamino acid metabolism" K00600+K00681+K01188+K01424+K01426+K01501+K05349 13 7 19 0.18 2716.06 0.17 339.89 0.27 598.29 0.28 881.15 0.10 896.74 0.30 00350 "Tyrosine metabolism" K00001+K00055+K00135+K00151+K00157+K00450+K00457+K00492+K00599+K00812+K00813+K00817+K00832+K01555+K01593+K01800 54 16 128 1.23 14049.66 0.90 997.32 0.78 1879.57 0.87 8452.03 0.92 2720.73 0.90 00791 "Atrazine degradation" K01428+K01429+K01430+K01457+K03382 11 5 19 0.18 1730.25 0.11 26.23 0.02 24.70 0.01 1669.02 0.18 10.29 0.00 01056 "Biosynthesis of type II polyketide backbone" K05554 5 1 2 0.02 230.24 0.01 0.12 0.00 0.66 0.00 227.27 0.02 2.19 0.00 00624 "1- and 2-Methylnaphthalene degradation" K00001+K00120+K00155+K00480+K00492+K01041+K03384 13 7 77 0.74 5346.20 0.34 28.01 0.02 94.71 0.04 5191.86 0.57 31.62 0.01 00590 "Arachidonic acid metabolism" K00432+K00465+K00681+K00687 28 4 18 0.17 2765.82 0.18 339.05 0.26 593.47 0.28 938.16 0.10 895.13 0.29 00626 "Naphthalene and anthracene degradation" K00120+K00155+K00465+K00480+K00492+K00517+K00599+K01563+K03380 12 9 128 1.23 15532.51 0.99 1269.54 0.99 2444.70 1.14 8248.05 0.90 3570.22 1.18 00290 "Valine, leucine and isoleucine biosynthesis" K00052+K00053+K00161+K00162+K00163+K00263+K00826+K00835+K01649+K01652+K01653+K01687+K01703+K01704+K01754+K01869+K01870+K01873+K09011 20 19 173 1.66 12502.67 0.80 525.27 0.41 848.42 0.39 10100.39 1.10 1028.60 0.34 00473 "D-Alanine metabolism" K00824+K01775+K01921+K03367 4 4 45 0.43 3189.87 0.20 48.70 0.04 178.07 0.08 2894.52 0.32 68.58 0.02 00633 "Trinitrotoluene degradation" K00170+K00171+K00172+K00192+K00197+K03518+K03519+K03520+K06282+K10680+K11180+K11181 22 12 47 0.45 5103.23 0.33 399.65 0.31 643.14 0.30 3141.49 0.34 918.95 0.30